The bus will be launched after successful campaigns in neighbouring Schwyz and Schaffhausen.
While the vaccinations will be open to everyone, they will be targeted at people who find the registration process to be difficult, complicated or laborious.
Organisers are currently working with authorities in the various Zurich municipalities to determine where the bus will stop and at what times.
The bus will begin touring after the summer holidays, with specific dates and venues not yet determined.
Jörg Kündig, the president of the community presidents’ association, told SRF’s “Regionaljournal Zürich-Schaffhausen” on Wednesday morning that the final touches were being made to the bus campaign.
In total, 52.5 percent of people have been fully vaccinated in the canton of Zurich, which is 807,902 people.
This is the third highest percentage in all of Switzerland, after the southern canton of Ticino (52.96 percent) and Basel Country (52.51 percent).
This compares with 48.40 percent of the entire country who have been fully vaccinated, or 4,181,144 people.