Can you refuse to ‘mix and match’ Covid-19 vaccines in Italy?

After conflicting guidelines on the AstraZeneca vaccine, Italy's latest official advice is that no one under 60 should be offered the vaccine – including people who have already had the first dose. But those who are reluctant to switch vaccines for their second jab do have another option.

Can you refuse to 'mix and match' Covid-19 vaccines in Italy?
Italy recommends that people under 60 who got a first dose of the AstraZeneca vaccine follow it with either Moderna or Pfizer. Photo by MARCO BERTORELLO / AFP

After insisting earlier this month that under-60s who had already had one dose of the AstraZeneca vaccine should receive either Pfizer or Moderna for the second dose due to concerns over blood clots in a small number of younger recipients, the Italian Health Ministry has since revised its position to allow those who would prefer two shots of the same vaccine a choice.

In a circular issued on June 18th, the ministry said under-60s could choose to get a second dose of AstraZeneca’s Vaxzevria vaccine so long as they fully understood the possible side effects.

READ ALSO: Italy ‘strongly recommends’ AstraZeneca Covid vaccine for over-60s only

While the government continues to recommend that younger people get a booster shot of a different vaccine, if someone under 60 has been informed by health professionals of the potential risks of rare blood clots and still “refuses with no possibility of being convinced” to switch vaccines, the circular states, they can opt to get a second dose of AstraZeneca.

What Italy calls “vaccination crossing” – varying the first and second doses – is still the health ministry’s recommended option, and is approved as safe and effective by Italian medicines agency Aifa.

Several other EU countries including Germany, France, Spain, Sweden, Norway and Austria have also adopted the practice of following up a first AstraZeneca dose with a shot of Pfizer or Moderna. 

Why has the Italian government decided to allow people to choose AstraZeneca?

The latest guidance comes after Italy’s 20 regions, each of which is in charge of its own vaccination programme, issued varying rules about who could continue to get vaccinated with AstraZeneca, with some insisting they would continue to give second doses to younger adults and others threatening to ban the vaccine altogether.

There were also concerns over whether regions would have enough doses of the Pfizer and Moderna vaccines to go round, and whether the confusion might prompt people to give up on getting a second dose at all.

Ensuring that people get fully vaccinated is crucial, the government’s Covid-19 Technical and Scientific Committee (CTS) said when it was asked to decide on the question – especially as data shows that one dose is significantly less effective against some new coronavirus variants.

READ ALSO: How much is the Delta variant spreading in Italy?

The small number of blood clots reported after vaccination with AstraZeneca mostly occurred soon after the first dose, the CTS pointed out, with symptoms estimated to be more than ten times rarer after the second jab: around 1.3 cases in a million, according to data from the UK. In Italy, no cases of blood clots after the second dose have been reported to date.

Data from millions of people vaccinated with AstraZeneca across Europe and the UK indicates that serious side effects after either dose are extremely rare, and the vaccine remains approved for everyone over 18 by both EU and Italian drug regulators.

With all these factors in mind, the CTS recommends that people be allowed to exercise freedom of choice when it comes to their own health.

Photo by Alberto PIZZOLI / AFP

How to request a second dose of AstraZeneca

Under-60s who choose to stick with the AstraZeneca vaccine are required to sign an “informed consent” form when they go to get their second shot, stating that they are aware the government recommends they switch to a so-called mRNA vaccine, that they understand the risks and benefits, have had the chance to ask questions and received information that was clearly explained.

Don’t be afraid to ask questions or ask for a translation: the form specifically states that you should be informed in a language and way that you understand. 

The form must be signed by both the patient (or their legal representative) and the doctor on duty at the vaccination centre, as well as another health worker if available. 

Find the form here (pages 16-17), along with information about each of the four vaccines currently in use in Italy and their potential side effects.

What are the different types of Covid-19 vaccine available in Italy?

AstraZeneca and Johnson & Johnson are both so-called viral vector vaccines that use a genetically engineered version of a common cold virus to carry instructions into cells, telling them to reproduce spike proteins similar to those found on the coronavirus. 

When exposed to the real virus later, the body recognises the spike proteins and is able to fight them off.

READ ALSO: Italian PM Draghi changes Covid vaccines for second dose

Both vaccines are approved in Italy and the EU for adults of all ages, but have been linked to a small number of unusual blood clots, mostly in women under 60 who had received the shot in the past three weeks. Some of these clots were fatal.

The EU and Italy have also authorised two mRNA vaccines: Pfizer-BioNTech and Moderna. The mRNA or Messenger RNA genetic technology train cells to reproduce spike proteins without the need for a viral carrier. 

The immune system then recognises and fights off the coronavirus spike proteins in the same way as for other vaccines.

Member comments

Log in here to leave a comment.
Become a Member to leave a comment.


Italy approves fourth Covid vaccine doses for over-60s

Italy has extended the availability of a second Covid-19 vaccine booster shot as infection rates surge across the country.

Italy approves fourth Covid vaccine doses for over-60s

The Italian health ministry announced that fourth Covid vaccine doses, or second booster shots, will soon be available to all residents aged 60 and over, as national medicines regulator Aifa gave the green light on Monday.

Health minister Roberto Speranza said on Monday that doses could be administered to this age group “immediately”, as Italy “moves in line” with recommendations from the European Medicines Agency (EMA) and the European Centre for Disease Prevention and Control (ECDC).

“In the coming hours, immediately, already today, we will adapt our guidelines, our circulars and our indications. We will immediately open up administration in our regions.

“We mustn’t think that the battle against Covid is won. It is still ongoing and we must keep the level of caution high,” he said.

The health ministry confirmed in an update on its website that second booster doses were now recommended to “all persons aged 60 years or older, provided there has been an interval of at least 120 days since the first booster dose or the last post-booster infection (date of positive diagnostic test)”.

READ ALSO: Fourth jabs and isolation: Italy’s plan to control Covid cases this summer

The availability of fourth doses will vary by region, as each local health authority is responsible for managing the timing of its own vaccination campaign.

Several regions, including Lazio (around Rome) and Lombardy (around Milan), said on Monday that they would allow over-60s to book their fourth jabs within the coming days.

A fourth dose can be booked as usual, via pharmacies or family doctors, and via regional booking websites where available. (Find more information in a separate article here.)

Speranza didn’t say when second booster shots may be rolled out to all age groups, stating only that “a new vaccination campaign” is set to begin in September.

Health authorities have previously said they are not planning to make a fourth dose mandatory, though an annual “top-up” shot is likely to be offered.

Until now, only over-80s, care home residents, and clinically vulnerable patients have been eligible for a fourth shot in Italy.

READ ALSO: At a glance: What are the Covid-19 rules in Italy now?

But health experts are also urging the government to speed up the administration of fourth jabs to these vulnerable groups: uptake remains far lower than hoped so far, with 78 percent of over-80s not getting theirs yet.

With the coronavirus infection rate now at its highest level since February, and the number of hospitalisations expected to keep rising in the coming weeks, the health ministry has not said whether it plans to bring back any recently-scrapped health measures.

For now, the government’s strategy appears to be focused on maintaining the relatively high rate of vaccination coverage in Italy: 90 percent of the population over 12 years old has been fully vaccinated with at least two doses, official figures show.

Find out more about booking a booster shot in Italy in a separate article here. See the government’s ‘prenotazione vaccino‘ (vaccine booking) website for links to regional authorities’ appointment reservation platforms.