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ASTRAZENECA

Italy approves ‘mix and match’ vaccinations for under-60s as regions issue varying rules on AstraZeneca

The Italian Medicines Agency (Aifa) on Tuesday approved giving people under 60 a combination of Covid-19 vaccines after the government limited use of the AstraZeneca jab.

Italy approves 'mix and match' vaccinations for under-60s as regions issue varying rules on AstraZeneca
Under-60s in Italy may now have the Pfizer-BioNTech or Moderna Covid-19 vaccines instead of a second dose of AstraZeneca. Photo: Marco Bertorello/AFP

The health ministry said anyone under 60 who had already received a first dose of AstraZeneca should now have Pfizer or Moderna – so-called mRNA vaccines – for the second dose.

READ ALSO: Italy limits use of AstraZeneca vaccines to over-60s

Aifa on Monday published its approval for mixed vaccines. The regulator had previously recommended that people get both doses of the same vaccine.

The health ministry stated on Saturday that regional health authorities should stop giving the AstraZeneca jab to under-60s, amid concerns about heightened health risks for younger people.

Italian authorities had previously recommended AstraZeneca be only given to over-60s, but this was not an outright ban and many regions had been giving it to younger people on a voluntary basis. This advice was strengthened after the latest review last week.

However, despite the health ministry’s new instructions, Italy’s regions are continuing to implement their own vaccine programmes with varying rules.

Vials of the AstraZeneca (L) and Moderna Covid-19 vaccines at the pharmacy of the Sant’Andrea hospital in Vercelli, Piedmont. Photo: MARCO BERTORELLO/AFP

Italian news agency Ansa reported “chaos in the regions” on Tuesday, saying the latest rule-change on AstraZeneca had “caused confusion”.

Some Italian regional authorities said they will still continue to allow people to take AstraZeneca if they want to amid concerns about the supply of other vaccines, while Campania said it was banning the use of the Astrazeneca and Johnson and Johnson vaccines altogether.

EXPLAINED: Why has Italy recommended the AstraZeneca vaccine for over-60s only?

Vincenzo De Luca, regional president of Campania, announced that he had written to the health minister saying his region was against giving mixed vaccinations and claiming that the practice “has not been trialled broadly on an international level”.

In an interview with La Stampa on Monday, Health Minister Roberto Speranza stressed that mixing vaccinations was known to be safe and effective, saying: “Our indications are peremptory and must be followed. It is not a political debate. It’s not the prime minister, ministers or a regional president who decides:”

“So-called ‘vaccination crossing’ is something Germany has been doing for two months, which France and Spain have also been doing for some time,” he said. “It’s not made up, these are scientific studies. This is a procedure that has given good results.”

Several other EU countries including Sweden, Norway and Austria are also allowing people to have an mRNA shot for their second dose if they were first vaccinated with AstraZeneca, after those countries also changed their advice on the jab.

READ ALSO: Is Italy really going to offer vaccines to tourists this summer?

The European Medicines Agency (EMA) has stressed that the AstraZeneca jab remains approved for all adults, saying the benefits continue to outweigh the risks.

Meanwhile the Italian region of Puglia said it would allow people to take AstraZeneca if approved by their doctor, and Lombardy’s regional government expressed concerns about the supplies of Pfizer and Moderna vaccines.

Several regions have found themselves with unused doses of the Oxford University vaccine, as people opt to get vaccinated with alternatives that they perceive as safer or that have a shorter interval between doses (or in the case of Johnson & Johnson, require just one shot). 

As a result, some regions had been offering the Covid-19 vaccine to younger adults as part of vaccination “open days”: special vaccination drives, often at evenings or weekends, that allow the youngest age groups to get a shot earlier than they otherwise might.

The latest review of the use of AstraZeneca in Italy came following the news that an 18-year-old in north-west Italy who was vaccinated with AstraZeneca two weeks previously had died after developing a blood clot.

Most of the AstraZeneca side effects observed so far occurred within two weeks of the first dose. The second dose is thought to carry an even lower risk, though more data is needed to know for sure.

Data from millions of people vaccinated with AstraZeneca across Europe and the UK indicates that serious side effects after either dose remain extremely rare.

In a monitoring report released this week, AIFA said that in Italy the incidence of blood clots after vaccination was around one per 100,000 injections of AstraZeneca, mainly in people under 60. 

It has not received reports of any clots developing after the second dose, the agency said.

What are the different types of Covid-19 vaccine available?

AstraZeneca Johnson & Johnson, both so-called ‘viral vector’ vaccines, are authorised for everyone over 18 in Italy and by Europe’s medicines agency, but both have been dogged by reports of rare blood clots. 

The EU and Italy have also authorised two mRNA vaccines: Pfizer/BioNTech and Moderna.

Viral vector vaccines like AstraZeneca and Johnson & Johnson use genetically-engineered version of a common-cold causing adenovirus as a “vector” to shuttle genetic instructions into human cells.

The mRNA or Messenger RNA genetic technology instead trains the body to reproduce spike proteins, similar to that found on the coronavirus. 

When exposed to the real virus later, the body recognises the spike proteins and is able to fight them off.

Member comments

  1. My son is a student in England and has gotten his first Pfizer shot. I am wondering if he can get his second Pfizer shot in Italy as he will be with us for the summer. This is not only a question of logistics but also of reciprocity between the two countries. For example, will he be able to get his Italian green pass if he does the second shot in Italy and will England recognize it? Would appreciate any information on this. Thank you.

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COVID-19 VACCINES

Italy approves fourth Covid vaccine doses for over-60s

Italy has extended the availability of a second Covid-19 vaccine booster shot as infection rates surge across the country.

Italy approves fourth Covid vaccine doses for over-60s

The Italian health ministry announced that fourth Covid vaccine doses, or second booster shots, will soon be available to all residents aged 60 and over, as national medicines regulator Aifa gave the green light on Monday.

Health minister Roberto Speranza said on Monday that doses could be administered to this age group “immediately”, as Italy “moves in line” with recommendations from the European Medicines Agency (EMA) and the European Centre for Disease Prevention and Control (ECDC).

“In the coming hours, immediately, already today, we will adapt our guidelines, our circulars and our indications. We will immediately open up administration in our regions.

“We mustn’t think that the battle against Covid is won. It is still ongoing and we must keep the level of caution high,” he said.

The health ministry confirmed in an update on its website that second booster doses were now recommended to “all persons aged 60 years or older, provided there has been an interval of at least 120 days since the first booster dose or the last post-booster infection (date of positive diagnostic test)”.

READ ALSO: Fourth jabs and isolation: Italy’s plan to control Covid cases this summer

The availability of fourth doses will vary by region, as each local health authority is responsible for managing the timing of its own vaccination campaign.

Several regions, including Lazio (around Rome) and Lombardy (around Milan), said on Monday that they would allow over-60s to book their fourth jabs within the coming days.

A fourth dose can be booked as usual, via pharmacies or family doctors, and via regional booking websites where available. (Find more information in a separate article here.)

Speranza didn’t say when second booster shots may be rolled out to all age groups, stating only that “a new vaccination campaign” is set to begin in September.

Health authorities have previously said they are not planning to make a fourth dose mandatory, though an annual “top-up” shot is likely to be offered.

Until now, only over-80s, care home residents, and clinically vulnerable patients have been eligible for a fourth shot in Italy.

READ ALSO: At a glance: What are the Covid-19 rules in Italy now?

But health experts are also urging the government to speed up the administration of fourth jabs to these vulnerable groups: uptake remains far lower than hoped so far, with 78 percent of over-80s not getting theirs yet.

With the coronavirus infection rate now at its highest level since February, and the number of hospitalisations expected to keep rising in the coming weeks, the health ministry has not said whether it plans to bring back any recently-scrapped health measures.

For now, the government’s strategy appears to be focused on maintaining the relatively high rate of vaccination coverage in Italy: 90 percent of the population over 12 years old has been fully vaccinated with at least two doses, official figures show.

Find out more about booking a booster shot in Italy in a separate article here. See the government’s ‘prenotazione vaccino‘ (vaccine booking) website for links to regional authorities’ appointment reservation platforms.

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