Milan mayor Giuseppe Sala announced on Monday that Obama would be taking part in the Global Food Innovation Summit between May 8th and 11th this year.
Together with his White House chef Sam Kass, Obama will hold a conference on the impact of technological innovation on climate change and food. The event will take place on May 9th, confirmed Sala, who first announced that Obama had been invited to the summit last month.
"It will probably be [Obama's] first public outing since being president, and the fact that he has chosen Milan seems extraordinary to me," said Sala, describing the visit as "an honour".
Obama will also be handed the keys to the northern city in a symbolic ceremony.
During his time as president, Obama visited Rome and his wife Michelle and daughters attended the Milan Expo as well as travelling to Vicenza and Venice.
In Milan, the First Lady promoted her 'Let's Move!' programme aimed at encouraging American children to be more active and follow a healthy diet.
Mayor Giuseppe Sala said on Monday he was convinced she had told her husband "good things about the city" following her visit.
Obama enjoyed a close relationship with ex-Italian premier Matteo Renzi, whom he invited to his final state dinner at the White House. On that occasion, Renzi praised Michelle Obama for a speech given in support of women's rights, and even offered some words of praise for her homegrown tomatoes.