Residents on via Nomentana have put their business prowess into action and are charging up to €1,000 a day to those who want to watch the scene live, the British daily, The Mirror reported.
The move could net them up to €4,000 for the four-day shoot, which gets underway on March 7th.
The residents are hoping most of the demand will come from rich Russians, who they believe would happily stump up the price to see 007 Daniel Craig in action in Sceptre, the 24th Bond installment.
Giuliano Pintus, a porter, told the newspaper: "Everyone in my building is very excited because they have a fantastic view of the street, and are selling tickets for the night and inviting friends for big parties."
The scene will see Craig stop outside Villa Torlonia, the private residence of the Italian dictator Benito Mussolini, before being chased down secret tunnels and bunkers that were built to protect Mussolini's family.
Craig will also reportedly be filmed parachuting out of a helicopter and onto Rome's Ponte Sisto, a narrow 15th-century pedestrian bridge across the River Tiber that is itself a replacement for an earlier walkway dating back to the fourth century.
Sceptre is set for release in November and also stars the Italian actress, Monica Bellucci.
The film is being directed by Britain's Sam Mendes, the acclaimed theatre director responsible for the phenomenally successful 23rd installment of the Bond story, Skyfall.
As well as for via Neomontana property owners, the shooting of scenes in Rome also represents a boost for the capital's Cinecitta Studios, which is currently undergoing a revival of its fortunes.