The Golden globe-winner behind the music in "The Curious Case of Benjamin Button" and "New Moon" from the Twilight saga will be the first composer to lead the jury at the world's oldest film festival, taking place this year from August 27th to September 6th.
"Alexandre Desplat is not only one of today's great film composers but he is also a movie lover, whose artistic sensibility adds to a deep knowledge of cinema, its history, its language," the festival's director Alberto Barbera was quoted as saying.
Desplat has received six Academy Award nominations for films including "The Queen", "Fantastic Mr Fox" and "Philomena", and has worked with directors including Stephen Frears, Roman Polanski, Terrence Malick and George Clooney.
"It is a great honour and an arduous responsibility to be president of the jury at such a prestigious festival," Desplat said.
"Italian cinema has done more to influence both my taste and my music than anything else," he added.